Aggrenox®

MATCH

Bleeding Complications Increased Significantly

Take home message

What are the practical outcomes of MATCH?

Adding ASA to clopidogrel in high-risk patients with recent ischaemic stroke or transient ischaemic attack is associated with a non-significant difference in reducing major vascular events. However, the risk of life-threatening or major bleeding is increased more than twice by the addition of ASA.

References

Diener et al. Lancet 2004; 364: 331-337.
Lancet Abstract