Danish Headache Study
There were no significant changes between the ratio between plasma levels during infusion of placebo, adenosine 80 µg kg-1 min-1 or 120 µg kg-1 min-1, and baseline (p=0.228).
Mean Plasma Adenosine Concentrations
Baseline compared with response during the infusion of placebo, adenosine 80 µg kg-1 min-1 (80) or 120 µg kg-1 min-1 (120). Measurements were reproducible, but revealed no changes in adenosine due to the short half-life.
Conclusion
These results show that circulating adenosine has no effect on rCBF or VMCA, while it dilates the STA and causes very mild headache.
References
Birk et al. Cephalalgia 2005; 25: 369-377.
PubMed Abstract
