Danish Headache Study
Results
Six participants developed headache during 80 µg kg-1 min-1 and six during 120 µg kg-1 min-1 compared with none on placebo (p=0.006). The headache was very mild and predominantly described as a pressing sensation. VMCA decreased significantly over time after both adenosine 80 and 120 µg kg-1 min-1 (p<0.001), but not after placebo (p=0.19).
When correcting data for adenosine-induced hyperventilation, no significant changes in rCBF (p=0.22) or VMCA (p=0.16) were found between treatments.
Mean Flow Velocity in the Middle Cerebral Artery (VMCA)
